RESUMO
Intracavitary Californium-252 combined with whole-pelvis photon radiotherapy was tested as the sole form of treatment for 22 patients with Stage IB carcinoma of the cervix. Californium-252 (Cf) is a fast neutron-emitting radioisotope currently being tested in trials of neutron brachytherapy (NT). The outcomes of the treated group of patients were traced for local tumor control, survival, patterns of failure, and complications. The Cf intracavitary therapy combined with whole-pelvis photon radiotherapy resulted in 95% 2-year and 91% 5-year actuarial survival. There were 9% Grade II-III complications by the Stockholm scale and 4% local failures. These results were obtained in an early clinical trial with a group of largely poor-risk patients with tumors of mean diameter of 4.3 cm.
Assuntos
Braquiterapia , Califórnio/uso terapêutico , Neoplasias do Colo do Útero/radioterapia , Análise Atuarial , Adenocarcinoma/radioterapia , Adulto , Idoso , Braquiterapia/efeitos adversos , Califórnio/efeitos adversos , Carcinoma de Células Pequenas/radioterapia , Carcinoma de Células Escamosas/radioterapia , Ensaios Clínicos como Assunto , Nêutrons Rápidos/uso terapêutico , Feminino , Humanos , Pessoa de Meia-Idade , Recidiva Local de Neoplasia , Estadiamento de Neoplasias , Dosagem Radioterapêutica , Radioterapia de Alta Energia/efeitos adversos , Neoplasias do Colo do Útero/patologiaRESUMO
Bone scans were obtained in patients with adenocarcinoma of the uterus in order to search for occult skeletal metastases. Radiological studies in 350 patients with adenocarcinoma of the uterus treated at the University of Kentucky Medical Center were reviewed. All patients studied in Stage 1A, Stage 1BG1, and Stage G2 were negative. Bone scans performed since 1973 were reviewed. One out of 11 patients studied with G3 lesions had a positive scan. Four out of 41 patients with Stage 2 lesions had positive scans, seven out of 18 in Stage 3, and two out of nine in Stage 4 disease. Four out of 71 patients with recurrent tumor had positive scans. In general, all positive scans were associated with significant symptoms in the patients studied. The results correlated well with x-ray findings as evaluated by conventional radiologic studies.
